Global Symposium: Exercise Hormones and Future Therapies for Parkinson's (2023)

In this webinar, Dr. Ted Dawson, a renowned expert in neurodegenerative diseases, delved into the transformative impact of exercise on Parkinson's disease. Dr. Dawson's distinguished research endeavors have been centered on unraveling the molecular intricacies of this illness and probing potential avenues for therapeutic intervention. His laboratory's pioneering work unveiled the pivotal role of the exercise hormone, irisin, in bolstering cognitive function and mitigating brain inflammation.

Dr. Dawson's presentation shed light on irisin's potential as a preventive measure against dopamine neuron degeneration and the motor deficits stemming from pathological alpha-synuclein in Parkinson's disease. Irisin was shown to diminish the levels of pathological alpha-synuclein and facilitate its degradation through the endolysosomal system. Notably, endurance exercise emerged as the most effective method for stimulating irisin production. Furthermore, Dr. Dawson outlined plans for the development of recombinant irisin, slated for human trials within the next three to five years. This promising research promises a hopeful trajectory for those affected by Parkinson's disease.

**Disclaimer: These sessions are designed to provide general education and are not intended for individual advice and/or clinical care. The information conveyed in this recording was accurate at the time of presentation.**