From Genetics to Therapeutics (2017)

During this talk at the 2016 Parkinson Society BC Annual General Meeting, Stefano Cataldi, a PhD student, presents his research on Parkinson's disease, focusing on the role of genetics and mouse models in deepening the understanding of the disease. The talk highlights the hallmark characteristics of Parkinson's, such as dopamine depletion and motor symptoms, including tremors and reduced movement speed. He delves into the genetic aspects, emphasizing the connection between specific mutations in proteins like alpha-synuclein and the onset of Parkinson's.

The session sheds light on the creation of mouse models carrying these mutations. He discusses the results of in vivo experiments involving mice, revealing heightened dopamine levels at a young age, akin to observations in humans with distinct mutations. These findings hold promise in identifying individuals at risk of developing Parkinson's before neuronal loss occurs, thereby facilitating early interventions. Additionally, cellular studies demonstrate that neurons from mice carrying the mutation exhibit increased neurotransmitter release at a higher frequency, providing a modifiable system to probe the mechanisms underlying Parkinson's and explore potential therapeutic strategies.

**Disclaimer: These sessions are designed to provide general education and are not intended for individual advice and/or clinical care. The information conveyed in this recording was accurate at the time of presentation.**