Parkinson's Medications: Levodopa (2020)

In this webinar, Pharmacist Amy Tran discussed the use of levodopa in Parkinson's disease. Levodopa is considered the gold standard for treating the motor symptoms of Parkinson's disease. While it is effective for symptoms like slow movement and stiffness, it may not be as effective for tremors and freezing of gait. Levodopa works by replenishing depleted dopamine in the brain, but its response and duration of action can vary from person to person. It is best taken on an empty stomach and should be spaced from iron and protein to optimize absorption. Some common side effects include nausea, vomiting, orthostatic hypotension, confusion, hallucinations, and motor complications such as wearing off and dyskinesia.

Amy discussed the motor complications that can occur in Parkinson's disease, including on-off fluctuations and dyskinesia. She emphasizes that motor complications can vary from person to person and are influenced by factors such as age, levodopa dosage, disease severity, and disease duration. The talk also provides strategies for managing motor complications, such as optimizing levodopa regimen, adjusting protein intake, addressing constipation, and considering alternative therapies

Finally, she discussed the considerations for using natural health products in Parkinson's disease. She highlighted the importance of assessing the dosage reliability, consistency, and potential impurities in these products, emphasizing their differing regulation from traditional medications. Amy also cautioned about potential interactions and insufficient components in natural sources of levodopa that may affect its metabolism and lead to side effects. She stressed consulting with a pharmacist to ensure the safety and effectiveness of natural health products for Parkinson's.

View the video slides accompanying this presentation by clicking here.

**Disclaimer: These sessions are designed to provide general education and are not intended for individual advice and/or clinical care. The information conveyed in this recording was accurate at the time of presentation.**